Obesity, as we know, creates all sorts of problems. But now there’s a new one! Dementia.
Science Daily reports:
“Early to mid-life obesity appears to be linked to heightened risk of dementia in later life, researchers report. There is a threefold risk for those with severe obesity in their 30s, the observational study indicates.
Estimates suggest that almost 66 million people around the globe will have dementia by 2030, with the numbers predicted to top 115 million by 2050.
There is growing evidence that obesity is linked to dementia, but the research indicates that risk may be heightened or lowered, depending on age. And as yet, no study has looked at the age related effect of obesity on dementia risk across the whole age range in the population of one country.
So the researchers decided to do this, using anonymized data from hospital records for the whole of England for the period 1999-2011. Data in which obesity had been recorded were then searched for any subsequent care for, or death from, dementia.
During the study period, 451 232 of those admitted to hospital in England were diagnosed with obesity, 43% of whom were men.
The analysis revealed an incremental decrease in overall risk of hospital admission for dementia the older a person was when a diagnosis of obesity was first recorded, irrespective of gender.
For those aged 30-39, the relative risk of developing dementia was 3.5 times higher than in those of the same age who were not obese. For those in their 40s, the equivalent heightened risk fell to 70% more; for those in their 50s to 50% more; and for those in their 60s to 40% more.
People in their 70s with obesity were neither at heightened or lowered risk of developing dementia, while those in their 80s were 22% less likely to develop the disease, the findings indicated.
There were some age differences between the risk of developing vascular dementia or Alzheimer’s disease, with those in their 30s at greater risk of both. A diagnosis of obesity in the 40s through to the 60s was associated with an increased risk of vascular dementia, while the risk of Alzheimer’s disease was lower in those diagnosed with obesity from their 60s onwards.
This is an observational study, so no definitive conclusions can be drawn about cause and effect. But the findings confirm smaller published studies from elsewhere which report an increased risk of dementia in young people who are obese, but a reduced risk in older obese people, say the researchers.
They venture that a possible explanation for the particularly high risk found in early to mid-life may lie in the fact that heavier weight is associated with diabetes and cardiovascular risk factors, which are themselves linked to a heightened risk of dementia.
And it would seem that if people can stave off significant weight gain until at least their 60s, or survive long enough with obesity, they may have a lower risk of developing dementia, they suggest.
“While obesity at a younger age is associated with an increased risk of future dementia, obesity in people who have lived to about 60-80 years of age seems to be associated with a reduced risk,” they conclude.
And now for the common garden variety ways obesity can ruin our lives…
As your body mass index rises, so does your risk for coronary heart disease(CHD). CHD is a condition in which a waxy substance called plaque (plak) builds up inside the coronary arteries. These arteries supply oxygen-rich blood to your heart.
Plaque can narrow or block the coronary arteries and reduce blood flow to the heart muscle. This can cause angina. or a heart attack. (
Obesity also can lead to heart failure. This is a serious condition in which your heart can’t pump enough blood to meet your body’s needs.
High Blood Pressure
Blood pressure is the force of blood pushing against the walls of the arteries as the heart pumps blood. If this pressure rises and stays high over time, it can damage the body in many ways.
Your chances of having high blood pressure are greater if you’re overweight or obese.
Stroke
Being overweight or obese can lead to a buildup of plaque in your arteries. Eventually, an area of plaque can rupture, causing a blood clot to form.
If the clot is close to your brain, it can block the flow of blood and oxygen to your brain and cause a stroke. The risk of having a stroke rises as BMI increases.
Type 2 Diabetes
Diabetes is a disease in which the body’s blood glucose, or blood sugar, level is too high. Normally, the body breaks down food into glucose and then carries it to cells throughout the body. The cells use a hormone called insulin to turn the glucose into energy.
In type 2 diabetes, the body’s cells don’t use insulin properly. At first, the body reacts by making more insulin. Over time, however, the body can’t make enough insulin to control its blood sugar level.
Diabetes is a leading cause of early death, CHD, stroke, kidney disease, and blindness. Most people who have type 2 diabetes are overweight.
Abnormal Blood Fats
If you’re overweight or obese, you’re at increased risk of having abnormal levels of blood fats. These include high levels of triglycerides and LDL (“bad”) cholesterol and low levels of HDL (“good”) cholesterol.
Abnormal levels of these blood fats are a risk factor for CHD. For more information about triglycerides and LDL and HDL cholesterol, go to the Health Topics High Blood Cholesterol article.
Metabolic Syndrome
Metabolic syndrome is the name for a group of risk factors that raises your risk for heart disease and other health problems, such as diabetes and stroke.
You can develop any one of these risk factors by itself, but they tend to occur together. A diagnosis of metabolic syndrome is made if you have at least three of the following risk factors:
- A large waistline. This is called abdominal obesity or “having an apple shape.” Having extra fat in the waist area is a greater risk factor for CHD than having extra fat in other parts of the body, such as on the hips.
- A higher than normal triglyceride level (or you’re on medicine to treat high triglycerides).
- A lower than normal HDL cholesterol level (or you’re on medicine to treat low HDL cholesterol).
- Higher than normal blood pressure (or you’re on medicine to treat high blood pressure).
- Higher than normal fasting blood sugar (or you’re on medicine to treat diabetes).
Cancer
Being overweight or obese raises your risk for colon, breast, endometrial, and gallbladder cancers.
Osteoarthritis
Osteoarthritis is a common joint problem of the knees, hips, and lower back. The condition occurs if the tissue that protects the joints wears away. Extra weight can put more pressure and wear on joints, causing pain.
Sleep Apnea
Sleep apnea is a common disorder in which you have one or more pauses in breathing or shallow breaths while you sleep.
A person who has sleep apnea may have more fat stored around the neck. This can narrow the airway, making it hard to breathe.
Obesity Hypoventilation Syndrome
Obesity hypoventilation syndrome (OHS) is a breathing disorder that affects some obese people. In OHS, poor breathing results in too much carbon dioxide (hypoventilation) and too little oxygen in the blood (hypoxemia).
OHS can lead to serious health problems and may even cause death.
Reproductive Problems
Obesity can cause menstrual issues and infertility in women.
Gallstones
Gallstones are hard pieces of stone-like material that form in the gallbladder. They’re mostly made of cholesterol. Gallstones can cause stomach or back pain.
People who are overweight or obese are at increased risk of having gallstones. Also, being overweight may result in an enlarged gallbladder that doesn’t work well.
Overweight and Obesity-Related Health Problems in Children and Teens
Overweight and obesity also increase the health risks for children and teens. Type 2 diabetes once was rare in American children, but an increasing number of children are developing the disease.
Also, overweight children are more likely to become overweight or obese as adults, with the same disease risks.
Hmmm, perhaps dementia is one way of getting out of the pain of ‘normal’ obesity!
